Depression and anxiety are the most common psychiatric conditions seen in the general medical setting, affecting millions of individuals in the United States. The treatments for depression and anxiety are multiple and have varying degrees of effectiveness. Physical activity has been shown to be associated with decreased symptoms of depression and anxiety. Physical activity has been consistently shown to be associated with improved physical health, life satisfaction, cognitive functioning, and psychological well-being. Conversely, physical inactivity appears to be associated with the development of psychological disorders. Specific studies support the use of exercise as a treatment for depression. Exercise compares favorably to antidepressant medications as a first-line treatment for mild to moderate depression and has also been shown to improve depressive symptoms when used as an adjunct to medications. While not as extensively studied, exercise has been shown to be an effective and cost-efficient treatment alternative for a variety of anxiety disorders. While effective, exercise has not been shown to reduce anxiety to the level achieved by psychopharmaceuticals.
Saeed SA, Antonacci DJ, Bloch RM. Saeed SA, et al. Am Fam Physician. 2010 Apr 15;81(8):981-6. Am Fam Physician. 2010. PMID: 20387774 Review.
Paluska SA, Schwenk TL. Paluska SA, et al. Sports Med. 2000 Mar;29(3):167-80. doi: 10.2165/00007256-200029030-00003. Sports Med. 2000. PMID: 10739267 Review.
Andersson E, Hovland A, Kjellman B, Taube J, Martinsen E. Andersson E, et al. Lakartidningen. 2015 Nov 17;112:DP4E. Lakartidningen. 2015. PMID: 26574804 Review. Swedish.
Rebar AL, Stanton R, Geard D, Short C, Duncan MJ, Vandelanotte C. Rebar AL, et al. Health Psychol Rev. 2015;9(3):366-78. doi: 10.1080/17437199.2015.1022901. Epub 2015 Jul 3. Health Psychol Rev. 2015. PMID: 25739893
Burnett-Zeigler I, Schuette S, Victorson D, Wisner KL. Burnett-Zeigler I, et al. J Altern Complement Med. 2016 Feb;22(2):115-24. doi: 10.1089/acm.2015.0038. Epub 2015 Nov 5. J Altern Complement Med. 2016. PMID: 26540645 Free PMC article. Review.
Pasqualette L, Fidalgo TKDS, Freitas-Fernandes LB, Souza GGL, Imbiriba LA, Lobo LA, Volchan E, Domingues RMCP, Valente AP, Miranda KR. Pasqualette L, et al. Metabolites. 2024 Aug 15;14(8):450. doi: 10.3390/metabo14080450. Metabolites. 2024. PMID: 39195546 Free PMC article.
Philippi KFA, Zeier P, Brahmer A, Neuberger EWI, Sandner M, Hagenah M, Porten T, Lenz R, Ochmann DT, Wedekink F, Wischhusen J, Lutz B, Lieb K, Wessa M, Simon P. Philippi KFA, et al. J Med Internet Res. 2024 Aug 8;26:e53145. doi: 10.2196/53145. J Med Internet Res. 2024. PMID: 39116428 Free PMC article. Clinical Trial.
Hossain MN, Lee J, Choi H, Kwak YS, Kim J. Hossain MN, et al. Phys Act Nutr. 2024 Jun;28(2):43-51. doi: 10.20463/pan.2024.0015. Epub 2024 Jun 30. Phys Act Nutr. 2024. PMID: 39097997 Free PMC article.
Dhachpramuk D, Sonjaipanich S, Theppiban S, In-Iw S. Dhachpramuk D, et al. BMC Med Educ. 2024 Aug 2;24(1):837. doi: 10.1186/s12909-024-05843-y. BMC Med Educ. 2024. PMID: 39095768 Free PMC article.
Li Y, Zhou L, Xiao L, Wang H, Wang G. Li Y, et al. Neurochem Res. 2024 Sep;49(9):2615-2635. doi: 10.1007/s11064-024-04180-2. Epub 2024 Jun 21. Neurochem Res. 2024. PMID: 38904910